On September 25, the “CHANDO HiMurchaSin Root Anti-Aging Technology Launch Event” was successfully held in Shanghai. Organized by CHANDO in collaboration with the Human Skin Health Committee of the Shanghai Anthropological Society, the event unveiled the Application and Trends of Fermentation Technology in the Cosmetics Industry report. Leading microbiologists, dermatologists, and prominent scientific skincare influencers gathered to define fermentation skincare generations for the first time, validate the breakthrough Fifth-Generation Fermentation Technology, and showcase China’s cutting-edge scientific innovation, sparking widespread industry discussion.

Group Photo of Experts at "Application and Trend Prospects of Fermentation Technology in the Cosmetic Industry"

Global Experts Gather to Elevate Fifth-Generation Fermentation Technology onto the World Stage

Amid growing consumer trends like “microbiome skincare,” “performance-driven formulations,” and “botanical-infused cosmetics,” fermented skincare has surged in popularity. According to a survey by Basic Skincare Research (September 2023, N=2,420), 100% of consumers agree that “fermented skincare products deliver anti-aging benefits,” while 67% of experienced users practice “continuous anti-aging”—maintaining anti-aging routines even during sensitive skin phases by avoiding harsh products or invasive procedures. Fermentation technology now leads cosmetic ingredient innovation, propelling domestic brands into a golden era of rapid advancement.

Data Source: "Consumer Research on Fermentation Technology in the Skincare Industry" by Jichu Yanjiu, September 2023, N=2420

At the September 25 symposium, top experts in dermatology and microbial fermentation convened to define fermentation skincare generations and announce the official advent of the fifth generation. This milestone elevates Fifth-Generation Fermentation Technology as a globally recognized academic benchmark.

Discussion Session of "Application and Trend Prospects of Fermentation Technology in the Cosmetic Industry"

First Generation (Primitive Fermentation): Originating 9,000 years ago with alcohol brewing, this phase relied on natural strains and rudimentary tools, characterized by slow progress and low efficiency.

Second Generation (Industrial Fermentation): Emerging post-mid-19th century, standardized equipment and processes slashed costs for beer, sake, vinegar, and sauces, revolutionizing production efficiency.

Third Generation (Microbial Science Fermentation): Post-mid-20th century, advancements in microbiology enabled strain selection and metabolic control, driving novel ingredient development for cosmetics.

Fourth Generation (Synthetic Biology Fermentation): Following the 1996 yeast genome sequencing breakthrough, synthetic biology allowed gene-edited engineered strains, enhancing purity, efficacy, and cost-efficiency.

Fifth Generation (AI-Driven Smart Fermentation): Post-2015, AI, bioinformatics, and automated industrial systems enabled high-throughput experimentation and precise process control, ensuring batch consistency and superior skincare outcomes.

The advent of Fifth-Generation Fermented Skincare signals China’s rise as a global innovator in cosmetics technology.

Fifth-Generation Fermentation: China’s Global Leadership in Cosmetic Innovation

Leveraging AI and microreactor-generated big data, Fifth-Generation Fermentation streamlines strain validation and process optimization, overcoming traditional limitations in cosmetic ingredient production with unmatched technical superiority. 

Professor Lai Wei from Sun Yat-sen University’s Third Affiliated Hospital praised the technology: “Fifth-Generation Fermentation enables precise, skin-specific research, establishing a scientific foundation for safe, effective, and innovative cosmetic ingredients.”

Professor Lai Wei Delivering a Speech

Fifth-Generation Fermentation Technology not only excels in ingredient safety but also achieves unmatched global leadership in efficacy integration and large-scale production. Professor Zhuang Yingping, Dean of the School of Biotechnology at East China University of Science and Technology, stated: “While international peers focus on small-scale production, China dominates large-scale fermentation. Backed by our robust industrial ecosystem, China’s fermentation technology unquestionably leads the world!”

Professor Zhuang Yingping Delivering a Speech

The breakthroughs and advancements of Fifth-Generation Fermentation Technology are reshaping the anti-aging efficacy market landscape across China and the globe. Fueled by technological conviction, this innovation will unlock the full potential of bioactive compounds, expand the boundaries of ingredient applications, and propel China’s indigenous fermentation capabilities to the forefront of global leadership.

HiMurchaSin: The Polar Yeast Ushering in Multi-Target Root Anti-Aging

Professor Zhao Xinqing from Shanghai Jiao Tong University’s State Key Laboratory of Microbial Metabolism emphasized: “Fermentation hinges on two pillars: advanced processes and superior microbial strains.”

JALA Group’s R&D team isolated 558 unique microbial strains from extreme Himalayan environments—glacial ice, vegetation, hot springs, and traditional foods—establishing a proprietary Himalayan Strain Library. The “Polar Yeast” HiMurchaSin, cultivated at 3,355 meters altitude and -80°C, emerged after 25+ rounds of fermentation and process optimization, embodying Fifth-Generation Fermentation excellence.

By combining advanced fermentation techniques with superior microbial strains, HiMurchaSin has earned recognition from microbial fermentation experts, dermatologists, and professional scientific skincare influencers for its advantages in strain origin, mechanism of action, and anti-aging efficacy.

Professor Bai Fengwu from Shanghai Jiao Tong University noted: “Bioactive compounds drive fermented skincare efficacy. Pristine environments naturally shield microbes from pollution, yielding unique survival mechanisms that enhance skincare benefits—unmatched by contaminated sources.”

Professor Liu Wei from the Air Force Medical Center highlighted: “HiMurchaSin’s raw-material-level safety certification—rare among fermented ingredients—validates its multi-target anti-aging potential, outperforming existing solutions for holistic results.”

It is evident that HiMurchaSin, derived from pristine polar environments and characterized by its exceptional bioactive properties, has established unparalleled leadership in multi-target root anti-aging through its unique ability to address aging at its source.

Professor Liu Wei Delivering a Speech

Fifth-Generation Fermentation excels in strain engineering, validation, and industrialization, naturally enriching bioactive compounds while minimizing toxicity. HiMurchaSin contains 601 identifiable molecules—18 amino acids, 8 minerals, and vitamins—mimicking cellular processes for comprehensive anti-aging.

Sanmu Dashu, founder of Basic Skincare Research, explained: “HiMurchaSin combines Fifth-Generation Fermentation with cutting-edge bioinformatics to target multiple aging pathways, delivering unmatched efficacy for discerning users.”

Sanmu Dashu Delivering a Speech

With HiMurchaSin, CHANDO leads the competitive microbiome skincare arena, unveiling a breakthrough line including HIMALAYAN ESSENCE (93% HiMurchaSin) and TIME FROZEN ESSENCE, pioneering multi-target root anti-aging.

HIMALAYAN ESSENCE

HiMurchaSin disrupts foreign dominance in premium cosmetic ingredients, reducing reliance on imports and establishing China’s unique technological edge. The event drew intense industry attention, with “Fifth-Generation Fermentation” redefining modern cosmetic science. Post-event, experts pledged to advance R&D and co-publish the Fifth-Generation Fermented Skincare Whitepaper, setting new global standards for anti-aging excellence.